Components Of

Platelet Rich Plasma

Growth factors are biologically active polypeptide molecules. They interact with specific cell surface receptors leading to responses that are dictated by the receptor mediated signal transduction pathways of the target cells. Growth factors are unique in that they stimulate the growth or proliferation of these target cells. Along with stimulating proliferation, growth factors cause a number of other biological processes to occur.

Growth Factor Components of PRP

• PDGF (Platelet derived growth factor)

• TGF-αβ (Transforming growth factor alpha & beta)
  EGF (Epidermal growth factor)

• FGF (Fibroblast growth factor)
  IGF (Insulin growth factor)

• PDEGF (platelet derived epidermal growth factor)

• PDAF (platelet derived angiogenesis factor)

• IL-8 (Interleuking-8)

• TNF-α (Tumor necrosis factor alpha)

• CTGR (Connective tissue growth factor)
  GM-CSF (Granulocyte macrophage colony stimulating factor)

• KGF (Keratinocyte growth factor)

• High concentration of leukocytes (neutrophils, eosinophils) for microbicidal events

• High concentration of wound macrophages and other phagocytic cells, for biological debridement

• Histamines, Serotonin, ADP, Thromboxane A2, and other vasoactive and chemotactic agents
  High platelet concentration and native fibrinogen concentration for improved hemostasis

Key Cellular Components of PRP

• Platelets

• Neutrophil (PMN) - 40-75% of circulating leukocytes

• Monocyte macrophage - 2-10% of circulating leukocytes. Highly motile and migrate to soft tissues

• Fibroblast - produce collagen, reticular fibers, glycosaminoglycans, glycoprotein

• Endothelial Cell - permeability barrier, regulate blood flow and vascular reactivity, vasodilators, vasoconstrictors, regulate inflammation and immunity

• Keratinocyte - Stratified, squamous epithelial cells Primary function is to act as a barrier